Glycidol → HCID 14638280, compound

Participants

Reaction Steps

A suspension containing 0.96 g of 4-(4-ethoxycarbonyl-1-piperazinyl)-2-methyl-6,7-dihydro-8H-pyrimido[5,4-b][1,4]oxazin-7-one (Example 1), 0.44 g of 2,3-epoxy-1-propanol, 0.0966 g of tetra(n-butyl)-ammonium bromide and 20 ml of abs. benzene is boiled under stirring for 5 hours and left to stand at room temperature overnight. The crystals are filtered, washed with diisopropyl ethyl and dried to give 0.98 g (83%) of the product, m.p.: 146°-148° C.

Provenance & Evidence