Ammonium Carbonate → HCID 178518413, compound

Participants

Reaction Steps

29.2 g (0.136 mol) of 14d in ethanol/water are reacted with 55 g (0.573 mol) of ammonium carbonate and 10.4 g (0.212 mol) of sodium cynanide in analogy to Example 1c. After removal of ethanol by distillation, the solution is acidified with 2N HCl to pH 2 at 0° C., then the pH is returned to 4.5 and the solution is extracted several times with ethyl acetate. The combined ethyl acetate phases are washed with sodium chloride solution, dried and evaporated.

Provenance & Evidence