Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | HCID 178497362 | HCID 178497362 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178432216 | HCID 178432216 | — |
Reaction Steps
27.8 g (10.146 mol) of 18b in 500 ml of THF are treated with 365.4 ml (0.438 mol) of DIBAL (20% strength solution in toluene) at -70° C. overnight in analogy to Example 1a. The crude product is vigorously stirred in boiling ethyl acetate and, after cooling to 20° C., the remaining material is filtered off with suction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04748163 |
|---|
| Source dataset | uspto-grants-1988_05 |
|---|
| ORD ID | ord-e2bc5a807c2644bfada20420d8366a42 |
|---|
| Source note | uspto-grants-1988_05 |
|---|
