反应详情

A mixture of 1.3 g of 3-nitropyridine-4-thiol in 4 ml of acetic acid and 15 ml of acetic anhydride containing 1.5 g of zinc dust was heated at reflux for four hours. The reaction mixture was cooled and concentrated to an oil. The oil was dissolved in 5N sodium hydroxide and the alkaline solution was extracted with diethyl ether. The extracts were combined, dried and concentrated to dryness to afford 557 mg of 2-methylthiazolo[4,5-c]pyridine. M+Theory 150; Found 150.

1. temperaturewas heated
2. temperatureat reflux for four hours
3. temperatureThe reaction mixture was cooled
4. concentrationconcentrated to an oil
5. dissolutionThe oil was dissolved in 5N sodium hydroxide
6. extractionthe alkaline solution was extracted with diethyl ether
7. customdried
8. concentrationconcentrated to dryness