Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Iodide → HCID 15671927, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | 1-Azabicyclo[2.2.2]octane-4-carboxamide | HCID 10130069 | — |
| 반응물 | (4-Methoxyphenyl)methyl (6R,7R)-3-(chloromethyl)-8-oxo-7-((2-phenylacetyl)amino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate | HCID 10874591 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | HCID 15671927 | HCID 15671927 | 33.9% |
반응 단계
p-Methoxybenzyl 7β-phenylacetamido-3-chloromethyl-3-cephem-4-carboxylate (980 mg) was suspended in acetone (20 ml), and sodium iodide (362 mg) was added to the suspension and stirred at room temperature for 1 hour. To the resulting suspension was added 4-carbamoylquinuclidine (313 mg) under ice-cooled condition, and the mixture was stirred for 2 hours. The reaction mixture was filtered, and diethyl ether (70 ml) was added to the filtrate. The deposited solid was filtered to obtain the desired product (500 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04748171 |
| 출처 데이터셋 | uspto-grants-1988_05 |
| ORD ID | ord-2adfb7a2894947a6ac8716409d2b2423 |
| 출처 메모 | uspto-grants-1988_05 |