HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 15671929, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1-Azabicyclo[2.2.2]octane-4-carboxamide | HCID 10130069 | — |
| Reactant | HCID 14621642 | HCID 14621642 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Diisopropyl Ether | HCID 7914 | — |
| Product | HCID 15671929 | HCID 15671929 | 196.1% |
Reaction Steps
To an ethyl acetate solution (465 ml) of p-methoxybenzyl 7β-formamido-3-iodomethyl-3-cephem-4-carboxylate (9.3 g) there was added dropwise over 1 hour under stirring while ice-cooling a mixed solution (176 ml) of methanol and ethyl acetate (1:4 v/v) containing 4-carbamoyl quinuclidine (2.94 g). After stirring for 30 minutes, the resulting precipitate was collected by filtration, followed by washing with ethyl acetate and then diisopropyl ether to obtain the desired product (12.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04748171 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-e225e94261a8404795efe1a598a1049f |
| Source note | uspto-grants-1988_05 |