反应详情

Tetrahydrothiopyran-2,6-dicarboxylic anhydride (2.4 g., 14 mmole) and 1-(4-aminobutyl)-4-(2-pyrimidinyl)piperazine (3.5 g., 15 mmole) were dissolved in 250 ml. of toluene and refluxed for 48 hours with water removal via a Dean-Shark trap. The solvent was removed in vacuum and replaced with chloroform. The mixture was filtered through 75 g. of silica gel and concentrated in vacuum and the residue was crystallized from isopropanol with addition of 4N isopropanolic HCl. A second crystallization from isopropanol gave 1. g. of the title compound as the monohydrochloride; m.p. 238°-241° C. (d).

1. customThe solvent was removed in vacuum
2. filtrationThe mixture was filtered through 75 g
3. concentrationof silica gel and concentrated in vacuum
4. customthe residue was crystallized from isopropanol with addition of 4N isopropanolic HCl
5. customA second crystallization from isopropanol
6. customgave 1