Formaldehyde → HCID 86742200, compound

HRID 1253280Notes

Reaction equation

HRID 1253280 reaction equation
[CH3:1][O:2][C:3](=[O:19])[CH2:4][C:5]1[O:6][CH:7]=[C:8](N)[C:9]2[C:10]=1[N:11]=[C:12]1[C:17]=2[CH:16]=[CH:15][CH:14]=[CH:13]1.[CH2:20]=[O:21]>CO>[CH3:1][O:2][C:3](=[O:19])[CH2:4][C:5]1[O:6][CH:7]=[C:8]([O:21][CH3:20])[C:9]2[C:10]=1[N:11]=[C:12]1[C:17]=2[CH:16]=[CH:15][CH:14]=[CH:13]1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 86742201HCID 86742201, compound

Product 1

HCID 86742200HCID 86742200, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

When the 4-aminopyrano[3,4-b]indole acetic acid methyl ester 12 was treated with aqueous formaldehyde in methanol, an 80% yield of 4-methoxypyrano[3,4-b]indole acetic acid methyl ester 16 was obtained as an 8.5:1 diastereomeric mixture.

Sources & evidence

ORD record
ord-91ace51a0870482e9883cb50e11e42e4
Source dataset
uspto-grants-1988_05
Patent number
US04748252

Reaction notes

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