Hydrogen Bromide → HCID 20137577, compound

Participants

Reaction Steps

2-(1-bromoethyl)-2-(5-bromo-6-methoxy-2-naphthyl)-5,5-dimethyl-1,3-dioxane (9.16 g, 10 mmol) is dissolved in toluene (40 ml) and nitrobenzene (2 g) saturated with HBr at room temperature. Phenol (11.28 g, 120 mmol) is added as solid; the mixture is stirred for 2.5 hours, then is poured in 30 minutes under stirring into a 10% aqueous sodium carbonate solution (150 ml), the organic layer is separated and the aqueous phase is extracted with toluene. The combined organic extracts are washed with water, dried on sodium sulphate and the solvent is removed in vacuo. 2-(1-bromoethyl)-2-(6-methoxy-2-naphthyl)-5,5-dimethyl-1,3-dioxane is obtained (75% yield).

Provenance & Evidence