Triphenylphosphine → HCID 54347543, compound

Participants

Reaction Steps

To a solution of triphenylphosphine (284 mg) in tetrahydrofuran (4 ml) cooled at -15° C. are added a 0.85M solution of chlorine in carbon tetrachloride (1.27 ml), triethylamine (0.152 ml), and a solution of ketodiester (4) (160 mg) in tetrahydrofuran (2 ml). The mixture is warmed to room temperature, stirred for 6.5 hours, subjected to usual work-up, and silica gel chromatography to give chlorodiester (5). Yield: 67%.

Provenance & Evidence