Triethylamine → HCID 58404820, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3-ethynyl-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine (20 mg, 0.08 mmol), 4-iodo-5-methyl-1-(2-thienyl)-1H-pyrazole (23 mg, 0.08 mmol), copper (I) iodide (4.5 mg, 0.024 mmol), and tetrakis(triphenylphosphine)palladium (0) (9.1 mg, 0.008 mmol) in N,N-dimethylformamide (2 ml), was added triethylamine (0.022 ml, 0.16 mmol). The mixture was sparged with argon for 3 minutes and heated to 70° C. After 1 h, reaction mixture was purified directly by preparative HPLC Reverse phase (C-18), eluting with acetonitrile/water+0.05% TFA to give 4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-{[5-methyl-1-(2-thienyl)-1H-pyrazol-4-yl]ethynyl}pyrazolo[1,5-a]pyridine.

Provenance & Evidence