N-Iodosuccinimide → HCID 67207989, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-methyl-2-(2-thienyl)-1H-imidazole (116 mg, 0.706 mmol) in acetonitrile (5 ml) was added NIS (159 mg, 0.706 mmol) at room temperature. The reaction mixture was heated in the Biotage Initiator Series microwave for 1 hour at 120° C. The reaction mixture was diluted in ethyl acetate, washed with 1N aqueous sodium hydroxide and brine then dried over sodium sulfate, filtered and concentrated to give 5-iodo-1-methyl-2-(2-thienyl)-1H-imidazole. The material was taken forward without any additional purification. LRMS (ESI) calculated for C8H8N2SI [M+H]+, 290.9; found 291.0.

Provenance & Evidence