Phenyl isocyanate → HCID 67374575, compound

Participants

Reaction Steps

To a solution of 4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}pyridin-2-amine (24 mg, 0.07 mmol) in dichloromethane (1400 μl) was added phenyl isocyanate (9.09 μl, 0.084 mmol) and the mixture was allowed to stir for 72 hours at room temperature. The precipitated solid was filtered was filtered and the washed with 10 mL of dichloromethane. The solid was dried in vacuo to afford N-(4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}pyridin-2-yl)-N′-phenylurea. 1H NMR (500 MHz, DMSO-d6) δ 10.28 (s, 1H); 9.46 (s, 1H); 8.69 (s, 1H); 8.28 (s, 1H); 8.23-8.21 (m, 2H); 8.01 (s, 1H); 7.56 (s, 1H); 7.47 (d, 2H); 7.26 (t, 2H); 7.04 (s, 1H); 6.98-6.96 (m, 2H); 4.05 (s, 3H); 3.82 (s, 3H). LRMS (ESI) calculated for C26H21N7O2 [M+H]+, 464.2; found 464.1.

Provenance & Evidence