tert-butyl 2-(2-ethoxy-2-oxoethyl)pyrrolidine-1-carboxylate → tert-Butyl 2-(2-oxoethyl)pyrrolidine-1-carboxylate

Temperature

-80 °C

Into a 3,000 ml 3-necked roundbottom flask purged and maintained with an inert atmosphere of nitrogen was placed a solution of tert-butyl 2-(2-ethoxy-2-oxoethyl)pyrrolidine-1-carboxylate (119 g, 463 mmol) in dichloromethane (1,200 ml). The solution was cooled to −80° C. and diisobutylaluminum hydride (362 g, 510 mmol) was added dropwise, while maintaining an internal temperature of −80° C. (3 hours total addition time). The resulting solution was allowed to stir for 2 hours while the temperature was maintained at −80° C. The reaction mixture was then quenched by the adding 500 ml of methanol. After warming to ambient temperature, the mixture was washed with 1,000 ml of NaOH (20% w/w aqueous) and 6 times with 1,000 ml of water. The organic layer was dried over sodium sulfate, filtered and concentrated to afford tert-butyl 2-(2-oxoethyl)pyrrolidine-1-carboxylate, which was used without additional purification.

1. customInto a 3,000 ml 3-necked roundbottom flask purged
2. temperaturemaintained with an inert atmosphere of nitrogen
3. temperaturewhile maintaining an internal temperature of −80° C. (3 hours total addition time)
4. temperaturewas maintained at −80° C
5. customThe reaction mixture was then quenched by the adding 500 ml of methanol
6. temperatureAfter warming to ambient temperature
7. washthe mixture was washed with 1,000 ml of NaOH (20% w/w aqueous) and 6 times with 1,000 ml of water
8. dry with materialThe organic layer was dried over sodium sulfate
9. filtrationfiltered
10. concentrationconcentrated

ORD record

ord-365fe2806cbb4ff09d98dcf93325cbb1

Source dataset

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08455477B2