Acetyl chloride → HCID 66701172, compound

HRID 1253686Notes

Reaction equation

HRID 1253686 reaction equation
C([Cl:4])(=O)C.[N:5]1([C:10]([CH:12]2[CH2:29][CH2:28][C:15]3([CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[CH2:14][CH2:13]2)=[O:11])[CH2:9][CH2:8][CH2:7][CH2:6]1>C(O)C>[ClH:4].[N:5]1([C:10]([CH:12]2[CH2:13][CH2:14][C:15]3([CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[CH2:28][CH2:29]2)=[O:11])[CH2:6][CH2:7][CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 67547941Tert-butyl 9-(pyrrolidine-1-carbonyl)-3-azaspiro[5.5]undecane-3-carboxylate

Product 1

HCID 66701172HCID 66701172, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethanol (4 ml) and acetyl chloride (0.23 ml, 0.66 mmol) were added to tert-butyl 9-(pyrrolidine-1-carbonyl)-3-azaspiro[5.5]undecane-3-carboxylate (0.25 g, 0.788 mmol) and the mixture was stirred at room temperature for 12 h. When the reaction was complete, the solvent was removed in vacuo. Yield: 0.18 g (96%)

Workup

  1. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-766841a416df4f069d4ceb7a463476c6
Source dataset
uspto-grants-2013_06
Patent number
US08455475B2

Reaction notes

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