HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1253693Generated: November 2, 2026
Trifluoroacetic acid → HCID 59505464, compound
https://huagongshe.com/reaction/1253693
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 66701118 | HCID 66701118 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59505464 | HCID 59505464 | — |
Reaction Steps
TFA (1 ml) was added to a cooled (0° C.) solution of tert-butyl 8-(4-(trifluoromethyl)phenyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (0.47 mmol, 1.0 eq.) in methylene chloride (3 ml) and the reaction mixture was stirred at 25° C. for 1 h. When the reaction was complete, the solvent was removed in vacuo in order to obtain the desired amine (AMN-23).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08455475B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-d7232baf10234b0fa0e9d011ecf6769d |
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| Source note | uspto-grants-2013_06 |
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