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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1253693Generated: November 2, 2026

Trifluoroacetic acid → HCID 59505464, compound

https://huagongshe.com/reaction/1253693

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 66701118HCID 66701118—
SolventDichloromethaneHCID 6344—
ProductHCID 59505464HCID 59505464—

Reaction Conditions

Temperature25 °C

Reaction Steps

TFA (1 ml) was added to a cooled (0° C.) solution of tert-butyl 8-(4-(trifluoromethyl)phenyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (0.47 mmol, 1.0 eq.) in methylene chloride (3 ml) and the reaction mixture was stirred at 25° C. for 1 h. When the reaction was complete, the solvent was removed in vacuo in order to obtain the desired amine (AMN-23).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08455475B2
Source datasetuspto-grants-2013_06
ORD IDord-d7232baf10234b0fa0e9d011ecf6769d
Source noteuspto-grants-2013_06