HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1253695Generated: November 2, 2026
Trifluoroacetic acid → 8-(Pyridin-3-yl)-2,8-diazaspiro[4.5]decane
https://huagongshe.com/reaction/1253695
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 8-(pyridin-3-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate | HCID 66700909 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-(Pyridin-3-yl)-2,8-diazaspiro[4.5]decane | HCID 59505578 | — |
Reaction Steps
TFA (2 ml) was added to a solution of tert-butyl 8-(pyridine-3-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate (1.14 mmol, 1.0 eq.) in methylene chloride (6 ml) at 0° C. and the reaction mixture was stirred at 25° C. for 2 h. When the reaction was complete, the solvent was concentrated in vacuo in order to obtain the desired amine (AMN-24).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08455475B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-851fae3a659e4785922cb37db6f186b2 |
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| Source note | uspto-grants-2013_06 |
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