反应详情

Acetyl chloride (5 eq.) was added to an ice-cold solution of tert-butyl 2-(pyridin-4-yl)-2,8-diazaspiro[4.5]decane-8-carboxylate (3.78 mmol, 1 eq.) in ethanol (14 ml). The reaction mixture was stirred at room temperature overnight. The solvent was concentrated in vacuo and the residue was dissolved in ethanol/acetone (2:1, 30 ml). The white solid which precipitated was filtered out, washed with diethyl ether and dried in vacuo. Yield: 98%

1. concentrationThe solvent was concentrated in vacuo
2. dissolutionthe residue was dissolved in ethanol/acetone (2:1, 30 ml)
3. customThe white solid which precipitated
4. filtrationwas filtered out
5. washwashed with diethyl ether
6. customdried in vacuo