反应详情

温度

25 °C

NaBH4 (13.46 mmol, 2.0 eq.) was added portion wise to a stirred solution of tert-butyl 9-(2-oxoethoxy)-3-azaspiro[5.5]undecane-3-carboxylate (6.73 mmol, 1.0 eq.) in MeOH (65 ml) at 0° C. and the resulting reaction mixture was stirred at 25° C. for 16 h. The solvent was evaporated under reduced pressure. The residue was dissolved in ethyl acetate (300 ml) and washed with water (200 ml) and brine (200 ml). The organic layer was dried over sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography eluting with 20% ethyl acetate in hexanes to give the desired product as a yellow sticky solid. Yield: 40%

1. customthe resulting reaction mixture
2. customThe solvent was evaporated under reduced pressure
3. dissolutionThe residue was dissolved in ethyl acetate (300 ml)
4. washwashed with water (200 ml) and brine (200 ml)
5. dry with materialThe organic layer was dried over sodium sulfate
6. concentrationconcentrated under reduced pressure
7. customto give the crude product
8. customThe crude product was purified by silica gel column chromatography
9. washeluting with 20% ethyl acetate in hexanes