Trifluoroacetic acid → 9-(2-(1H-Imidazol-1-yl)ethoxy)-3-azaspiro[5.5]undecane

Participants

Reaction Conditions

Reaction Steps

TFA (6.25 ml) was added to a solution of tert-butyl 9-(2-(1H-imidazol-1-yl)ethoxy)-3-azaspiro[5.5]undecane-3-carboxylate (2.28 mmol, 1.0 eq.) in MC (25 ml) at 0° C. and the mixture was stirred at 25° C. for 2 h. The reaction mixture was concentrated under reduced pressure and the residue was azeotroped with MC to give the crude product which was used in the next step without further purification.

Provenance & Evidence