Ammonia → HCID 59818872, compound

HRID 1253740Notes

Reaction equation

HRID 1253740 reaction equation
CS(O[CH2:6][CH2:7][C:8]1([CH2:22][CH2:23]OS(C)(=O)=O)[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]1)(=O)=O.[NH3:29]>CO>[CH2:7]1[C:8]2([CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]2)[CH2:22][CH2:23][NH:29][CH2:6]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86645839HCID 86645839, compound

Product 1

HCID 59818872HCID 59818872, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of tert-butyl 4,4-bis(2-(methylsulfonyloxy)ethyl)azepane-1-carboxylate (500 mg, 1.12 mmol), MeOH (2 ml) and NH3 solution (1.5 ml) was heated at 50° C. in a sealed tube for 16 h. The reaction mixture was concentrated under reduced pressure and the crude material was washed with hexanes and dried to afford the desired compound as a yellowish semi-solid which was used in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washthe crude material was washed with hexanes
  3. customdried

Sources & evidence

ORD record
ord-41c1183063b541b78975e8033822c88e
Source dataset
uspto-grants-2013_06
Patent number
US08455475B2

Reaction notes

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