6-Heptynoic acid → 7-(4-{4-[1-(2-Chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-phenyl)-hept-6-ynoic acid

HRID 1253768Notes

Reaction equation

HRID 1253768 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([O:10][C:11](=[O:26])[NH:12][C:13]1[C:14]([CH3:25])=[N:15][O:16][C:17]=1[C:18]1[CH:23]=[CH:22][C:21](Br)=[CH:20][CH:19]=1)[CH3:9].[C:27]([OH:35])(=[O:34])[CH2:28][CH2:29][CH2:30][CH2:31][C:32]#[CH:33]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([O:10][C:11]([NH:12][C:13]1[C:14]([CH3:25])=[N:15][O:16][C:17]=1[C:18]1[CH:23]=[CH:22][C:21]([C:33]#[C:32][CH2:31][CH2:30][CH2:29][CH2:28][C:27]([OH:35])=[O:34])=[CH:20][CH:19]=1)=[O:26])[CH3:9]

Participants

3

Reactant 2

HCID 43779506-Heptynoic acidHCID 67350786[5-(4-Bromophenyl)-3-methylisoxazol-4-yl]carbamic acid 1-(2-chlorophenyl)ethyl ester

Product 1

HCID 547680107-(4-{4-[1-(2-Chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-phenyl)-hept-6-ynoic acid

Procedure

Prepared according to the procedure described in Example 2, Step 1, using the following starting materials: [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid 1-(2-chloro-phenyl)-ethyl ester and 6-heptynoic acid. Mass spec. data (M+H)=481.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d148da76a8fb4b4e83fb987344c9be5c
Source dataset
uspto-grants-2013_06
Patent number
US08455499B2

Reaction notes

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