Lithium Hydroxide → HCID 70878224, compound

Participants

Reaction Conditions

Reaction Steps

To 5-(4-{4-[1-(2-chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-phenyl)-2,2-dimethyl-pent-4-ynoic acid ethyl ester (0.46 mmol) in MeOH and H2O was added lithium hydroxide, and the reaction was stirred at 60° C. overnight. The mixture was acidified and extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered, and concentrated, and the residue was purified by preparative HPLC to give the title compound. Mass spec. data (M+H)=481.

Provenance & Evidence