Picolinic acid → Pyridine-2-carboxylic acid [5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-amide

HRID 1253782ノート

反応式

HRID 1253782 の反応式
[CH:1]1([C:6]2[CH:7]=[C:8]([NH2:18])[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25](O)=[O:26]>>[CH:1]1([C:6]2[CH:7]=[C:8]([NH:18][C:25]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][N:19]=3)=[O:26])[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:15])([F:16])[F:17])[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

3

反応物 2

HCID 1018Picolinic acidHCID 712941725-Cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

生成物 1

HCID 71509734Pyridine-2-carboxylic acid [5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-amide収率 54.7%

実験手順

This compound was prepared following the same procedure as described for Example 3 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (Example 1c) (100 mg, 0.38 mmol) and pyridine-2-carboxylic acid (41 mg, 0.33 mmol) as starting materials. The title compound (66 mg, 46.8%) was isolated as off white solid; MS (ESI): 366 [M+H]+.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-4ca77382efe04250a5d1c76d68ee65d7
出典データセット
uspto-grants-2013_06
特許番号
US08455501B2

反応ノート

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