Nicotinic Acid → N-[5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-nicotinamide

HRID 1253786Notes

Reaction equation

HRID 1253786 reaction equation
[CH:1]1([C:7]2[CH:8]=[C:9]([NH2:19])[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:20](O)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[N:23][CH:22]=1>>[CH:1]1([C:7]2[CH:8]=[C:9]([NH:19][C:20](=[O:27])[C:21]3[CH:26]=[CH:25][CH:24]=[N:23][CH:22]=3)[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:16])([F:17])[F:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 712941485-Cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 71294357N-[5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-nicotinamideYield 43.1%

Procedure

This compound was prepared following the same procedure as described for Example 3 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (Example 8b) (100 mg, 0.36 mmol) and nicotinic acid (40.6 mg, 0.33 mmol) as starting materials. The title compound (54 mg, 39.9%) was isolated as off white solid; MS (ESI): 380 [M+H]+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-cb5a0653da844b48ac1482791282c841
Source dataset
uspto-grants-2013_06
Patent number
US08455501B2

Reaction notes

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