4-Bromo-3,5-dimethylphenol → 1-[3-(4-Bromo-3,5-dimethylphenoxy)propyl]pyrrolidin-2-one

HRID 1253805Notes

Reaction equation

HRID 1253805 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][C:6]1=[O:10].[Br:11][C:12]1[C:17]([CH3:18])=[CH:16][C:15](O)=[CH:14][C:13]=1[CH3:20]>>[Br:11][C:12]1[C:17]([CH3:18])=[CH:16][C:15]([O:1][CH2:2][CH2:3][CH2:4][N:5]2[CH2:9][CH2:8][CH2:7][C:6]2=[O:10])=[CH:14][C:13]=1[CH3:20]

Participants

3

Reactant 2

HCID 819704-Bromo-3,5-dimethylphenolHCID 5667441-(3-Hydroxypropyl)pyrrolidin-2-one

Product 1

HCID 681941901-[3-(4-Bromo-3,5-dimethylphenoxy)propyl]pyrrolidin-2-one

Procedure

According to the method of (Example 36) <Step 7>, from 1-(3-hydroxypropyl)pyrrolidin-2-one (3.8 mL) and 4-bromo-3,5-dimethylphenol (5.0 g), a crude product (14.6 g) containing the subject compound was obtained.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-b926c8a15a584391ab75d45392670da8
Source dataset
uspto-grants-2013_06
Patent number
US08455500B2

Reaction notes

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