Hydrochloric Acid → HCID 59420747, compound

Participants

Reaction Steps

2-(2,2,2-trifluoroethyl)-5-(triisopropylsilylthio)-isoindolin-1-one (1.39 g, 3.45 mmol) was dissolved in a solution of hydrochloric acid (6.7 ml, 1.25 M, 8.62 mmol) in methanol (10 ml) and tetrahydrofuran (10 ml) and stirred at room temperature for 2 hours. The reaction mixture was concentrated in vacuo to afford the desired compound as an off-white solid (0.783 g, 92% yield). 1H NMR (CDCl3, 400 MHz) 3.70 (1H, s), 4.22 (2H, q), 4.53 (2H, s), 7.35-7.39 (2H, m) and 7.76 (1H, d); MS (ES+) 248, (ES−) 246.

Provenance & Evidence