Trifluoroacetic acid → HCID 44137546, compound

Participants

Reaction Steps

To a solution of [(R)-3-oxo-3-(2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester (40 mg, 0.08 mmol) in DCM (5 mL), was added trifluoroacetic acid (0.24 mL, 3 mL/mmol). The reaction mixture was stirred at r.t. for 1 h. After completion of the reaction, as confirmed by TLC, excess of trifluoroacetic acid and DCM were evaporated in vacuo to afford a gummy solid which was solidified from hexane to afford trifluoroacetic acid salt of 4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-one (30 Mg, 73%) as a solid.

Provenance & Evidence