Trifluoroacetic acid → HCID 11333230, compound

Participants

Reaction Steps

To a solution of {benzyloxy carbonyl-(2-tert-butoxycarbonylamino-4,5-difluoro-benzyl)-amino]-acetic acid} (4.76 g, 10.56 mmol) in dry DCM (40 mL) was added trifluoroacetic acid (14.35 mL, 3 mL/mmol) at 0° C. The reaction mixture was stirred at r.t. for 2 h under argon. After completion of the reaction as confirmed by TLC, the reaction mixture was evaporated in vacuo to remove excess of solvent and trifluoroacetic acid. The remaining were removed under vacuo and 2-[(benzyloxycarbonyl-carboxymethyl-amino)-methyl]-4,5-difluoro, phenyl-ammonium trifluoroacetate (4.75 g, 97%) was obtained as thick brown jelly which was used as such without any further purification for the next step.

Provenance & Evidence