HCID 68639140, compound → HCID 68628824, compound

Participants

Reaction Steps

To a solution of [tert-butoxycarbonyl-(4-fluoro-2-nitro-benzyl)-amino]-acetic acid (5.11 g, 15.50 mmol) in absolute EtOH (30 mL), was added 10% Pd/C (1.02 g, 20% w/w). The reaction was stirred at r.t. for 5 h under hydrogen atmosphere. After completion of the reaction, as confirmed by TLC, the reaction mixture was filtered through celite bed and was washed with EtOAc (10 mL) and MeOH (10 mL). The solvents were removed in vacuo to afford 2-((2-amino-4-fluorobenzyl) (tert-butoxycarbonyl)amino) acetic acid (4.64 g, 99.9%), which was used as such far the next step without any further purification.

Provenance & Evidence