Ethanolamine → HCID 178452337, compound

Participants

Reaction Steps

2-aminoethanol (3.5 mL, 10 mL/mmol) was added to a solution of tert-butyl 2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate (100 mg, 0.35 mmol), [prepared as described in Example 6, Step 6] and the reaction mixture was heated to reflux for 24 h under nitrogen atmosphere. The reaction mixture was cooled to room temperature, diluted with ethylacetate (50 mL) and washed with water (20 mL). The organic layer was separated, dried over anhydrous sodium sulphate and concentrated to give the desired compound as viscous oil (100.0 mg, 90%) which was used as such for the next step.

Provenance & Evidence