Trifluoroacetic acid → HCID 68782311, compound

Participants

Reaction Steps

To a solution of [3-oxo-3-(4H,6H-3,5,10b-triaza-benzo[e]azulen-5-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester (30 mg, 0.06 mmol) in DCM (3 mL), was added trifluoroacetic acid (0.18 nit, 3 mL/mmol)). The reaction mixture was stirred at r.t. for 1 h. After the completion of the reaction as confirmed by TLC, excess of trifluoroacetic acid and DCM were removed in vacuo to afford a gummy solid which was crystallised from hexane to afford trifluoroacetic acid salt of 3-amino-1-(4H,6H-3,5,10b-triaza-benzo[e]azulen-5-yl)-4-(2,4,5-trifluoro-phenyl)-butan-1-one (30 mg, 98%).

Provenance & Evidence