HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 68777047, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid | HCID 7146288 | — |
| Reactant | HCID 68776705 | HCID 68776705 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 68777047 | HCID 68777047 | — |
Reaction Steps
4H,6H-1,2,5,10b-Tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester was deprotected using trifluoroacetic acid and the resulting salt was coupled with (R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid using HOBt, EDC and DIPEA. The desired compound was obtained as viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455479B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-034bc0c126b649a28b255a40cca2b1f8 |
| Source note | uspto-grants-2013_06 |