Trifluoroacetic acid → HCID 58497206, compound

Participants

Reaction Conditions

Reaction Steps

4-(5-Iodo-1-methyl-2-pyridin-2-yl-1H-imidazol-4-yl)benzohydrazide (4.9 g, 12 mmol) was suspended in 60 mL of triethyl orthoformate, to which was added 1 mL of TFA. The suspension was heated at 130° C. The reaction was cooled to rt, and the precipitate was collected, washed with hexanes and dried to give 4.8 g of the title compound. 1H NMR (500 MHz, (CDCl3): 8.62 (m, 1H), 8.57 (s, 1H), 8.11 (m, 1H), 8.09 (s, 4H), 7.82 (m, 1H), 7.32 (m, 1H), 4.13 (s, 3H). LCMS: [M+1]=430.

Provenance & Evidence