N-Iodosuccinimide → HCID 66986216, compound

Participants

Reaction Steps

The product of Step 1 (700 mg, 2.85 mmol) was dissolved in 10 mL of MeCN, to which was added NIS (770 mg, 3.42 mmol) and catalytic amount of TPA. After stirring at rt overnight, the reaction was diluted with EtOAc, washed with aq NaHCO3, aq Na2S2O3, water, and brine. The organic layer was dried over MgSO4, filtered, and concentrated to give 770 mg of 4-(5-iodo-2-phenyl-1H-imidazol-4-yl)benzonitrile. LCMS: [M+1]=372.

Provenance & Evidence