Iodoethane → HCID 44553561, compound

Participants

Reaction Steps

To 4-{5-[(4-chlorophenyl)thio]-2-phenyl-1H-imidazol-4-yl}benzonitrile (Example 2, 10 mg) in THF (1 mL) was added NaH (60% wt, 15 mg) at 0° C. After stirring for 5 min, EtI (0.05 mL) was added. The reaction was stirred at 50° C. overnight, then quenched with aq NH4Cl to adjust the pH to 6-8. The product was extracted with EtOAc and the combined extracts were washed with water, brine, dried over MgSO4, filtered, and concentrated. The residue was subject to silica column chromatography (0-15% EtOAc in hexanes) to give the title compound. LCMS: m/z 416 (M+H)+.

Provenance & Evidence