HCID 44554255, compound → HCID 44554254, compound

Participants

Reaction Steps

The title compound was prepared from 1-(4-{5-[(4-chlorophenyl)thio]-1-methyl-2-pyridin-2-yl-1H-imidazol-4-yl}phenyl)-2,2-difluoroethanone (Example 56) following the procedure described for Example 55. 1H NMR (500 MHz, (CDCl3): 8.65 (d, 1H), 8.38 (d, 1H), 8.04 (d, 2H), 7.84 (t, 1H), 7.39 (d, 2H), 7.36 (t, 1H), 7.26 (d, 2H), 7.03 (d, 2H), 5.74 (dt, 1H), 4.58 (m, 1H), 4.12 (s, 3H). LCMS: m/z 458 (M+H)+. The racemic alcohol was resolved on a Chiral AD-H column (20% EtOH/80% hexanes, flow rate 1 mL/min) to give two enantiomers: faster enantiomer's retention time=17.8 min; slower enantiomer's retention time=20.4 min.

Provenance & Evidence