HCID 44554253, compound → HCID 44554252, compound

Participants

Reaction Steps

The title compound was prepared from 1-(4-{5-[(4-chlorophenyl)thio]-1-methyl-2-pyridin-2-yl-1H-imidazol-4-yl}phenyl)-2,2,2-trifluoroethanone (Example 58) following the procedure described for Example 55. 1H NMR (500 MHz, (CDCl3): 8.64 (broad s, 1H), 8.39 (broad d, 1H), 7.84 (t, 1H), 7.36 (t, 1H), 7.25 (d, 2H), 7.23 (d, 2H), 7.06 (d, 2H), 7.03 (d, 2H), 4.59 (m, 1H), 4.15 (s, 3H). LCMS: m/z 476 (M+H)+.)+. The racemic alcohol was resolved on a Chiral OJ column (20% EtOH/80% hexanes, flow rate 1 mL/min) to give two enantiomers: faster enantiomer's retention time=15.8 min; slower enantiomer's retention time=18.9 min.

Provenance & Evidence