Pyrazole → HCID 44554075, compound

Participants

Reaction Conditions

Reaction Steps

To a microwave tube were added 2-[5-[(4-chlorophenyl)thio]-4-(4-iodophenyl)-1-methyl-1H-imidazol-2-yl]pyridine (Example 61, 150 mg, 0.30 mmol), CuI (57 mg, 0.30 mmol), pyrazole (61 mg, 0.89 mmol), N,N′-dimethylethylenediamine ((79 mg, 0.89 mmol), potassium t-butoxide (100 mg, 0.89 mmol), and 4 mL of NMP. The reaction was heated at 150° C. for 90 min via microwave. After filtration through Celite, the reaction mixture was purified by reverse phase HPLC to afford the title compound. 1H NMR (500 MHz, (CDCl3): 8.65 (d, 1H), 8.37 (d, 1H), 8.24 (d, 2H), 7.98 (broad s, 1H), 7.84 (t, 1H), 7.43 (d, 2H), 7.36 (t, 1H), 7.25 (d, 2H), 7.04 (d, 2H), 4.15 (s, 3H). LCMS: m/z 444 (M+H)+.

Provenance & Evidence