Hydroxylamine → HCID 44554073, compound

Participants

Reaction Conditions

Reaction Steps

To 4-{5-[(4-chlorophenyl)thio]-1-methyl-2-phenyl-1H-imidazol-4-yl}benzonitrile (Example 2, 30 mg, 0.075 mmol) in 2 mL EtOH was added 0.25 mL of HONH2 and catalytic amount of K2CO3. The reaction was heated at 120° C. for 60 min via microwave. The reaction mixture was concentrated to dryness and the residue was dissolved in 5 mL triethylorthoformate. Catalytic amount of TFA was added and the reaction was heated at 130° C. for 3 h. The volatiles were removed and the residue was purified by reverse phase HPLC to afford the title compound. 1H NMR (500 MHz, (CDCl3): 8.74 (s, 1H), 8.27 (d, 2H), 8.18 (d, 2H), 7.72 (m, 2H), 7.53 (m, 3H), 7.25 (d, 2H), 7.06 (d, 2H), 3.68 (s, 3H). LCMS: m/z 445 (M+H)+.

Provenance & Evidence