HCID 66992896, compound → HCID 44553898, compound

Participants

Reaction Conditions

Reaction Steps

To the crude product of Step 1 in 1 mL of THF was added 0.1 mmol of MeMgBr (3M in ether) at −78° C. After stirring at 0° C. for 1 hr, the reaction was quenched with aqueous NH4Cl, and the product was extracted with EtOAc. The combined extracts were concentrated and the crude product was purified by reverse phase HPLC to afford the title compound. 1H NMR (500 MHz, (CDCl3): 8.04 (d, 2H), 7.68 (m, 2H), 7.54 (d, 2H), 7.53 (m, 3H), 7.26 (d, 2H), 7.06 (d, 2H), 3.67 (s, 3H), 1.61 (s, 6H). LCMS: m/z 435 (M+H)+.

Provenance & Evidence