Hydrochloric Acid → HCID 44553894, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-(4-{5-[(4-chlorophenyl)thio]-1-methyl-2-phenyl-1H-imidazol-4-yl}phenyl)-2-methylpropanenitrile (Example 76, 120 mg, 0.270 mmol) in 3 mL of EtOH and 2 mL of 2 N NaOH was stirred at 90° C. over two days. The mixture was neutralized with 2 N HCl (pH=ca 5) and the product was extracted with EtOAc. The extracts were concentrated to dryness, and the residue was purified by reverse phase HPLC to afford the title compound. 1H NMR (500 MHz, (CD3OD): 7.88 (d, 2H), 7.74 (m, 2H), 7.58 (m, 3H), 7.44 (d, 2H), 7.26 (d, 2H), 7.31 (d, 2H), 3.64 (s, 3H), 1.58 (s, 6H). LCMS: m/z 462 (M+H)+.

Provenance & Evidence