Lithium Hydroxide → HCID 66986231, compound

Participants

Reaction Steps

A solution of methyl 4-(5-iodo-1-methyl-2-pyridin-2-yl-1H-imidazol-4-yl)benzoate (Intermediate 7, Step 3, 1.5 g, 3.58 mmol) and lithium hydroxide (0.257 g, 10.73 mmol) in acetonitrile (6 mL) and water (6 mL) was heated to 50° C. for 2 h. The mixture was concentrated and extracted with EtOAc. The organics were dried (MgSO4) and concentrated to afford 4-(5-iodo-1-methyl-2-pyridin-2-yl-1H-imidazol-4-yl)benzoic acid. LCMS: m/z 406.0 (M+H)+.

Provenance & Evidence