Hydroxylamine → HCID 136627687, compound

Participants

Reaction Steps

To a suspension of step 3 product C-5 (240 mg, 0.572 mmol) in EtOH (5 ml) was added hydroxylamine (199 mg, 2.86 mmol) and DMA (0.498 ml, 2.86 mmol). After stirred at rt for 10 min, the reaction mixture was heated at 80° C. for 2 hrs. and then concentrated. To the residue was added EtOAc and washed with Na2CO3 (aq), organic layer was dried, and concentrated to give 4-{5-[(4-chlorophenyl)sulfanyl]-2-(1-ethyl-1H-pyrazol-3-yl)-1-methyl-1H-imidazol-4-yl}-N′-hydroxybenzenecarboximidamide (230 mg), which was used for further reaction without purification. LCMS: [M+1]+=453.2.

Provenance & Evidence