HCID 57544689, compound → HCID 57544599, compound

Participants

Reaction Steps

tert-butyl (S)-2-((S)-3-((R)-5-ethoxy-1-phenylpentyl)piperidine-1-carboxamido)-3-cyclohexylpropylmethylcarbamate (40.7 mg, 0.071 mmol) was stirred in HCl/dioxane (4 N, 4 mL) at rt until no starting material remained. The solvent was removed to to give (3S)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-5-ethoxy-1-phenylpentyl)-piperidine-1-carboxamide (32.9 mg, 91%) as its HCl salt. 1H NMR (CD3OD) δ 0.9 (m, 3 H), 1.0 (m, 2 H), 1.11 (t, 3 H), 1.2-2.0 (20 H), 2.40 (m, 1 H), 2.65 (m, 1 H), 2.70 (s, 3 H), 3.93 (m, 1 H), 3.05 (m, 2 H), 3.31 (m, 1 H), 3.40 (q, 2 H), 3.91 (d, 1 H), 4.13 (m, 2 H), 7.13 (2 H), 7.19 (1 H), 7.28 (2 H). MS ESI +ve m/z 472 (M+1).

Provenance & Evidence