Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pentane | HCID 8003 | — |
| Reactant | 1-Bromo-2-(3-fluorophenoxy)benzene | HCID 18423510 | — |
| Reactant | HCID 178418306 | HCID 178418306 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178506689 | HCID 178506689 | — |
Reaction Steps
To a stirred solution of 1-(3-fluorophenoxy)-2-bromobenzene (1.27 g, 4.75 mmol) in THF (10 mL) at −70° C. was added 1.7 M t-BuLi in pentane (5.6 mL, 9.50 mmol) dropwise to keep the temperature below −70° C. The resulting solution was stirred at −70° C. for 30 min, and used for the next step directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08455521B2 |
|---|
| Source dataset | uspto-grants-2013_06 |
|---|
| ORD ID | ord-42b26cebf6c64a7a8133ceebef8d4ea8 |
|---|
| Source note | uspto-grants-2013_06 |
|---|
