HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 1-(3-(Methylamino)-2-(tosylamino)propyl)cyclohexanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 1-((1-Tosylaziridin-2-yl)methyl)cyclohexanol | HCID 59382831 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(3-(Methylamino)-2-(tosylamino)propyl)cyclohexanol | HCID 59383073 | — |
Reaction Steps
A solution of 1-((1-tosylaziridin-2-yl)methyl)cyclohexanol (270 mg, 0.87 mmol) and methylamine in MeOH was stirred at rt for 4 h and concentrated to give 1-(3-(methylamino)-2-(tosylamino)propyl)cyclohexanol. The crude product was used in the next step without purification. MS m/z 341 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455521B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-3840dc3580f9436997e91c934cfee437 |
| Source note | uspto-grants-2013_06 |