HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(3-Amino-2-(tosylamino)propyl)cyclohexanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-((1-Tosylaziridin-2-yl)methyl)cyclohexanol | HCID 59382831 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(3-Amino-2-(tosylamino)propyl)cyclohexanol | HCID 59383076 | — |
Reaction Steps
To a solution of 1-((1-tosylaziridin-2-yl)methyl)cyclohexanol (107 mg, 0.346 mmol) in MeOH (2 mL) was added satd aq ammonia (2 mL). The resulting solution was stirred at rt for 4 h and concentrated to give 1-(3-amino-2-(tosylamino)propyl)cyclohexanol which was used for the next step without purification. MS m/z 327 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455521B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-b9734c607d6a4cba812669de241c4602 |
| Source note | uspto-grants-2013_06 |