Dimethyl Sulfide → HCID 59383025, compound

Participants

Reaction Steps

To a solution of tert-butyl (S)-1-(2,2,2-trifluoroethylcarbamoyl)-2-cyclohexylethyl-carbamate (1.8 g, 5.1 mmol) in anhydrous THF (30 mL) was added 2 M BH3.Me2S in THF (25 mL, 50 mmol) and the mixture was stirred at rt for 3 d. The reaction was quenched with MeOH (20 mL), the solvent was removed in vacuo and the residue was purified by silica chromatography to give crude tert-butyl (S)-1-(2,2,2-trifluoroethylamino)-3-cyclohexylpropan-2-ylcarbamate (1.7 g).

Provenance & Evidence