Water → HCID 59382849, compound

Participants

Reaction Steps

To a mixture solution of tert-butyl (S)-1-(4-(t-butyldimethylsilyloxy)cyclohexyl)-3-(methylamino)propan-2-ylcarbamate (112 g, 209 mmol) and Et3N (52.8 g, 522 mmol) in CH2Cl2 (1200 mL) was added dropwise a solution of benzyl chloroformate (39 g, 230 mmol) in CH2Cl2 (40 mL) at −20° C. After stirring for an additional 2 h, water (400 mL) was added and the mixture was extracted with CH2Cl2 (2×200 mL). The organic layers were washed with brine, dried over MgSO4, and evaporated. The residue was purified by silica chromatography to afford crude tert-butyl (S)-1-(4-(t-butyldimethylsilyloxy)cyclohexyl)-3-(N-(benzyloxycarbonyl)-N-methylamino)propan-2-ylcarbamate (90 g) as an oil which was a mixture of two isomers. The isomers were separated by preparative HPLC. 1H NMR (CDCl3, 400 MHZ): δ=0.08(s, 6 H), 0.89(s, 9H), 1.28(m, 4 H), 1.40(d, 9 H), 1.59(m, 4 H), 2.96(d, 3 H), 3.05(d, 1 H), 3.15(d, 1 H), 3.45(t, 3 H), 3.90(s, 1 H), 5.12(d, 2 H), 7.33(m, 5 H).

Provenance & Evidence